Impact of Aerobic Exercise Training on Insulin Resistance and Plasma Lipocalin 2 levels in Obese Young Men

Obesity has been known as major public health problem, was reported to be associated with insulin resistance, type 2 diabetes mellitus and cardiovascular disorders. Therefore the purpose of this study was to examine the effects of Aerobic exercise training on Insulin Resistance and plasma lipocalin2 (as Lcn2) in obese young men. Thirty healthy young men (aged 27.83 ± 1.69 years, height 1.71± 5.37 cm, BMI 30.1 ± 1.49 kg/m2, mean ± SD) participated as subjects in this study. The subjects were randomly assigned to aerobic training group (n=15) or control group (n= 15). Aerobic training group underwent an 8-week intervention, with a frequency of 3 d/wk at an intensity corresponding to 65 – 80% maximum heart rate for 35 – 55 min. The results showed that body fat percent, WHR, BMI, were decreased ((P<0.05), in the training group compared with control group. Maximum oxygen consumption (VO2max) on the other hand, increases significant (P<0.05) in the training group compared with the control group. Adipokin lcn-2, LDL-c, TG, TC, and insulin resistance determined by HOMA-IR decreased (P<0.05) and HDL-c increased (P<0.05). hs-CRP, did not change in the aerobic training group compared with the control group. It seems that 8 weeks aerobic training induced change in adipose tissue, decrease plasma Lipocalin2 and improve insulin resistance in young obese men.